Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

BCV Campbell; WH van Zwam; M Goyal; BK Menon; DWJ Dippel; AM Demchuk; S Bracard; P White; A Dávalos; CBLM Majoie; A van der Lugt; GA Ford; NP de la Ossa; M Kelly; R Bourcier; GA Donnan; YBWEM Roos; OY Bang; RG Nogueira; TG Devlin; LA van den Berg; F Clarençon; P Burns; J Carpenter; OA Berkhemer; DR Yavagal; VM Pereira; X Ducrocq; A Dixit; H Quesada; J Epstein; SM Davis; O Jansen; M Rubiera; X Urra; E Micard; HF Lingsma; O Naggara; S Brown; F Guillemin; KW Muir; RJ van Oostenbrugge; JL Saver; TG Jovin; MD Hill; PJ Mitchell; PS Fransen; D Beumer; AJ Yoo; WJ Schonewille; JA Vos; PJ Nederkoorn; MJ Wermer; MA van Walderveen; J Staals; J Hofmeijer; JA van Oostayen; GJ Lycklama à Nijeholt; J Boiten; PA Brouwer; BJ Emmer; SF de Bruijn; LC van Dijk; J Kappelle; RH Lo; EJ van Dijk; J de Vries; PLM de Kort; WJJ van Rooij; JSP van den Berg; BAAM van Hasselt; LAM Aerden; RJ Dallinga; MC Visser; JCJ Bot; PC Vroomen; O Eshghi; THCML Schreuder; RJJ Heijboer; K Keizer; AV Tielbeek; HM den Hertog; DG Gerrits; RM van den Berg-Vos; GB Karas; EW Steyerberg; Z Flach; HA Marquering; MES Sprengers; SFM Jenniskens; LFM Beenen; R van den Berg; PJ Koudstaal; MM Brown; T Liebig; T Stijnen; T Andersson; H Mattle; N Wahlgren; E van der Heijden

Journal article

Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

BCV Campbell, WH van Zwam, M Goyal, BK Menon, DWJ Dippel, AM Demchuk, S Bracard, P White, A Dávalos, CBLM Majoie, A van der Lugt, GA Ford, NP de la Ossa, M Kelly, R Bourcier, GA Donnan, YBWEM Roos, OY Bang, RG Nogueira, TG Devlin Show all

Lancet Neurology | Published : 2018

DOI: 10.1016/S1474-4422(17)30407-6

Abstract

Background General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care. Methods For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombect..

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